It is a highly addictive substance that seemingly caused people that consumed it to become immune to pain, both physical and emotional. However, withdrawal from the drug is shown to be profoundly hard to experience, and users will do anything to take more Bliss rather than go without it. One of its known victims was Linka's cousin, Boris, who was responsible for getting Linka addicted by slipping Bliss into food that he gave her. Boris ultimately died from a combination of blood loss and a Bliss overdose, and his death convinced Linka to give up the drug.
The formula to create Bliss was destroyed by Captain Planet to ensure that the drug could never be manufactured again to harm more people. In the end of the episode, Verminous Skumm eats a piece of cheese that he doesn't realize is laced with Bliss. He realizes in horror that he has become addicted to his own drug.